Important Safety Information

The most common adverse reaction reported is vomiting.

Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures.

Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, incoordination, excessive dilation of pupils, blindness and disorientation.

Post-approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions.

The Elanco/Lilly Legacies

Elanco is a global, innovation-driven company that develops and markets products to improve animal health production in more than 75 countries. Elanco Companion Animal Health enables veterinarians to help pets live longer, healthier, higher quality lives.

Eli Lilly and Company is a leading innovation-driven corporation committed to developing a growing portfolio of first-in-class and best-in-class pharmaceutical products that help people live longer, healthier and more active lives. Lilly products treat depression, schizophrenia, attention-deficit hyperactivity disorder, diabetes, osteoporosis and many other conditions.